Is Botox Your Friend?
i-Newswire.com - Press Release And News Distribution - Using Botox for Migraine and Headache Treatment, Phase II Studies: "(I-Newswire) -
Studies of patients with chronic daily headache [CDH], a disabling headache disorder characterized by headaches and/or migraines that occur on 16 or more days each month.
--Between-group differences ( BOTOX vs. placebo ) on the number of headache-free days at day 180 did not reach statistical significance. However, significant differences compared to placebo were demonstrated on other measures, including a decrease in the frequency of headache episodes, a decrease of at least 50% in headache days, and a decrease in acute medication use.
-- Differences in favor of BOTOX were even more evident in a subgroup analysis of patients who were not taking other prophylactic medication to treat their headache, and were more robust still in a further subanalysis of these patients who were overusing acute pain medications. These latter results are especially meaningful since the overuse of pain medication for headache is associated with maintenance of chronic headache and considerable disability.
-- Treatment with BOTOX� was well-tolerated.
Based on these Phase II findings, Allergan can move forward with a large Phase III clinical trial program, currently scheduled to begin in late 2005, to investigate the safety and efficacy of BOTOX as a prophylactic therapy in migraine patients with CDH. Patients with CDH are at the more severe end of the headache/migraine spectrum, and currently available therapies typically provide inadequate relief to these patients due to intolerable side effects or other limitations. BOTOX is not currently approved by the FDA for the treatment of any headache disorder."
My Take:
While I am a bit queasy about the idea of being injected with a poisonous substance designed to kill certain nerves ... when I have a migraine, I'll try anything.
So bring it on. Options are good.
Studies of patients with chronic daily headache [CDH], a disabling headache disorder characterized by headaches and/or migraines that occur on 16 or more days each month.
--Between-group differences ( BOTOX vs. placebo ) on the number of headache-free days at day 180 did not reach statistical significance. However, significant differences compared to placebo were demonstrated on other measures, including a decrease in the frequency of headache episodes, a decrease of at least 50% in headache days, and a decrease in acute medication use.
-- Differences in favor of BOTOX were even more evident in a subgroup analysis of patients who were not taking other prophylactic medication to treat their headache, and were more robust still in a further subanalysis of these patients who were overusing acute pain medications. These latter results are especially meaningful since the overuse of pain medication for headache is associated with maintenance of chronic headache and considerable disability.
-- Treatment with BOTOX� was well-tolerated.
Based on these Phase II findings, Allergan can move forward with a large Phase III clinical trial program, currently scheduled to begin in late 2005, to investigate the safety and efficacy of BOTOX as a prophylactic therapy in migraine patients with CDH. Patients with CDH are at the more severe end of the headache/migraine spectrum, and currently available therapies typically provide inadequate relief to these patients due to intolerable side effects or other limitations. BOTOX is not currently approved by the FDA for the treatment of any headache disorder."
My Take:
While I am a bit queasy about the idea of being injected with a poisonous substance designed to kill certain nerves ... when I have a migraine, I'll try anything.
So bring it on. Options are good.
posted by Ron King at 5:49 PM
0 Comments:
Post a Comment
<< Home